Allergen-specific TH2 cells produce IL-4 and IL-13, which drive allergen-specific B cells to produce IgE. The specific IgE produced in response to the allergen binds to the high-affinity receptor for IgE on mast cells, basophils, and activated eosinophils. So basically the specific IgE produced is responsible now what is IgE? Common allergic reactions, such as hay fever, certain types of asthma, and hives are linked to an antibody produced by the body called immunoglobulin E (IgE). Each IgE antibody can be very specific, reacting against certain pollens and other allergens.